Meaning : The psychological state of being irritated or annoyed.
Synonyms : annoyance, irritation, vexation
Meaning : Something or someone that causes trouble. A source of unhappiness.
Example :
Washing dishes was a nuisance before we got a dish washer.
A bit of a bother.
He's not a friend, he's an infliction.
Synonyms : annoyance, bother, infliction, pain, pain in the ass, pain in the neck